Neil
Shay is a Notre Dame associate professor of biological sciences
who studies the biochemical mechanisms involved in nutrition and
metabolism. Currently he is researching the effect of soy foods
and isoflavones on cholesterol levels. Recently we asked him if
it is true that you are what you eat.
Notre Dame Magazine: A European we know arrived in the
United States not long ago and said he was stunned by the large
number of fat people he saw.
Shay: It's just so easy in our society to eat
high-calorie foods. You drive up, push a button in your car, the
window goes down, you speak into the microphone and out comes
the 12-piece deep-fried chicken dinner with mashed potatoes, gravy,
cole slaw, mayonnaise, and you go home and eat all that. Here's
what people don't understand: One 12-ounce Coke is about 150 calories.
If you are over your caloric balance each day by just 150 calories,
you will be roughly 50,000 calories in excess for the year. Since
it takes 3,500 calories to equal one pound of body fat, that means
one extra Coke per day can add about 15 pounds of fat to your
body each year.
NDM: Is the obesity problem in the United States really
as bad as some people say?
Shay: Adult-onset diabetes, what my mother used
to call "sugar diabetes" and doctors refer to as Type 2, is directly
related to obesity. Clinicians say we are in an epidemic of diabetes,
and the facts back them up. In 1994 there were just two states,
Louisiana and Mississippi, in which 6 percent or more of the population
were suffering from Type-2 diabetes. By 2002 that had spread to
33 states. It's how we're managing our lifestyles. This is a disease
of sitting on your rear, eating Twinkies and washing them down
with a 44-ounce Super Big Gulp of cola. Some nutrition researchers
believe the epidemic correlates with the increased use of high-fructose
corn syrup as a lower-cost alternative to sugar. It's used everywhere
now.
NDM: Knowing what you know, how do you manage your own
diet?
Shay: I try, as much as possible, to avoid fast-food
places, beverages sweetened with high fructose corn syrup and
food products containing transfatty acids, which are not metabolized
well by the liver and may be related to higher blood cholesterol
levels. Also, tilting toward a vegetarian diet is a good idea.
There's a lot of evidence that if you replace animal protein with
vegetable protein you will improve your blood lipids. Doctors
only rarely see vegetarians with high blood cholesterol levels.
NDM: You're looking now at methods to control cholesterol
with soy-based foods . . .
Shay: We have a number of projects that are
examining whether compounds known as isoflavones, which are found
in soy at high concentrations, have an effect similar to Lipitor
and other so-called "statin" drugs in reducing cholesterol levels
in the bloodstream.
NDM: How do isoflavones affect cholesterol levels?
Shay: We think soy isoflavones block the cholesterol-sensing
system in cells. So liver cells act as if they don't have enough
cholesterol in them, and they try to take up cholesterol from
their surroundings, out of the blood stream. Your body needs cholesterol.
It's a natural component of cell membranes; your body uses it
to form steroid hormones like estrogen and testosterone and vitamin
D. You just don't want excessive amounts in your bloodstream because
there it adheres to the lining of your blood vessels. That's a
problem.
NDM: Can isoflavones and statin drugs
work together?
Shay: We have some promising preliminary data
which suggests that certain combinations of isoflavones and statin
drugs, in fact, may be synergistic. They may enhance each other's
ability to remove cholesterol from the blood. We'd like to see
if we can design an optimal combination. Among other things, we're
also trying to confirm or deny whether isoflavones affect the
rate that Lipitor and other statin drugs are degraded by the liver.
The faster the liver breaks down the drug, the less effective
it is.
NDM: Is it possible to have too much soy?
Shay: One of our cell studies suggests that
at least one of the soy isoflavones can possibly accelerate the
degradation of a statin. However, I don't think a person has to
worry if they are just eating soy foods. It's more likely that
the level would be a problem only if someone ingested excessive
amounts of concentrated isoflavone supplement tablets. That's
a lot different than eating a soy burger. Sometimes, too much
can be as bad as too little. When something is concentrated in
pill form, you have to wonder if you are approaching the definition
of a drug.
(October 2004)
